NH4-6 is a SIRT2 inhibitor with an IC50 of 0.032 µM against SIRT2 and an IC50 of 3 µM against SIRT1. NH4-6 inhibits the deacetylase activity of SIRT1. As a cytotoxic agent, NH4-6 reduces cancer cell viability, suppresses anchorage-independent growth of cancer cells, induces acetylation of alpha-tubulin, and promotes acetylation of p53. NH4-6 can be used in the research of breast cancer[1].
Molecular Weight:
718.82
CAS Number:
[2375182-58-2]
Formula:
C33H59IN4O3S
Target:
Sirtuin
Application Notes:
MCE Product type: Reference compound
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