AG-012986 (dihydrochloride), CAS [[486414-32-8]] Preis auf Anfrage

Product Overview

• Article Name: AG-012986 (dihydrochloride), CAS [[486414-32-8]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-182470
• Supplier Catalog Number: HY-182470
• Alternative Catalog Number: MCE-HY-182470-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

AG-012986 dihydrochloride is a pan-CDK inhibitor with Ki values of 44 nM (CDK1), 9.2 nM (CDK4), 94 nM (CDK2), and IC50 values of 22 nM (CDK5), 4 nM (CDK9). AG-012986 dihydrochloride causes apoptosis of T-cells by targeting upstream kinases in the p38 Mitogen-activated protein kinase (MAPK) pathway and impairing cellular survival. AG-012986 dihydrochloride induces cell cycle arrest, retinoblastoma protein hypophosphorylation, and reduces Ki-67 expression. AG-012986 (dihydrochloride) can be used for the research of colon carcinoma, non-small cell lung carcinoma, breast carcinoma, ovarian tumor, pancreatic carcinoma, lymphoma, leukemia[1][2][3][4].

Product Properties

• Molecular Weight: 532.43
• CAS Number: [486414-32-8]
• Formula: C22H25Cl2F2N5O2S
• Target: CDK

Application Notes

• Application Notes: MCE Product type: Reference compound