KLK6-IN-1 is a reversible small-molecule inhibitor of KLK6, KLK1, and plasmin. KLK6-IN-1 shows IC50 values of 1.57 µM (KLK6), 5.1 µM (KLK1), 7.4 µM (plasmin), and Ki values of 0.8 µM (KLK6), 2.4 µM (KLK1), 1.3 µM (plasmin). KLK6-IN-1 is highly selective for KLK6 and its proteolytic network. KLK6-IN-1 induces oligodendrocyte differentiation by promoting oligodendrocyte precursor cell maturation. KLK6-IN-1 can be used for the research of multiple sclerosis[1].
Molecular Weight:
328.79
CAS Number:
[2370980-52-0]
Formula:
C18H17ClN2O2
Target:
Kallikrein,Plasminogen/Plasmin
Application Notes:
MCE Product type: Reference compound
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