CPL500036 is an orally active, blood-brain barrier permeable phosphodiesterase 10A (PDE10A) inhibitor with IC50 values of 1 nM (Reference 1) and 35 nM (Reference 2). CPL500036 acts as a negative allosteric modulator of the M2 muscarinic receptor with an IC50 of 9.2 µM. CPL500036 alters cyclic nucleotide levels in basal ganglia circuits, inhibits the hydrolysis of cAMP and cGMP, and suppresses hERG potassium channel tail currents. CPL500036 induces catalepsy in rats and reverses injury-induced contralateral forelimb use impairment. CPL500036 can be used in research related to schizophrenia, Parkinsons disease, and levodopa-induced dyskinesia[1][2].
Molecular Weight:
341.37
CAS Number:
[1829530-11-1]
Formula:
C19H15N7
Target:
mAChR,Phosphodiesterase (PDE),Potassium Channel
Application Notes:
MCE Product type: Reference compound
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