VGD020 is a highly potent and selective Sec61 translocon inhibitor. VGD020 suppresses the expression of cell surface CD4 by inhibiting signal peptide-dependent co-translational ER translocation, interferes with the initiation of ER translocation of dengue virus polyprotein, and reduces the expression of Sortilin in breast cancer cells. VGD020 exhibits broad anti-flavivirus and anti-HIV activities. VGD020 can be used in research related to dengue virus infection, Zika virus infection, yellow fever virus infection, human immunodeficiency virus infection, and breast cancer[1][2][3].
Molecular Weight:
603.84
CAS Number:
[1322645-32-8]
Formula:
C31H45N3O5S2
Target:
Flavivirus,HIV,Neurotensin Receptor,Sec61
Application Notes:
MCE Product type: Reference compound1
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