MMV085203 is a potent Plasmodium falciparum inhibitor, with a PfTrxR EC50 of 900 nM. MMV085203 exerts potent antimalarial activity against both blood-stage and sexual-stage Plasmodium falciparum parasites, with superior efficacy toward clinical isolates of high clonal diversity. MMV085203 modulates parasite redox homeostasis, induces ROS production, and elevates mitochondrial TCA cycle intermediates. MMV085203 can be used for the research of malaria[1][2].
Molecular Weight:
362.42
CAS Number:
[385419-89-6]
Formula:
C22H22N2O3
Target:
Parasite,Reactive Oxygen Species (ROS),TrxR
Application Notes:
MCE Product type: Reference compound
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