MRS7469 is a highly selective A1 adenosine receptor (A1AR) agonist with over 2000-fold selectivity over other adenosine receptor subtypes. MRS7469 stably binds to the orthosteric binding site of A1AR, and exhibits extremely high affinity for both humans and mice (e.g., human pKi is 8.67, mouse pKi is 9.43). By activating central A1AR, MRS7469 significantly induces hypothermia, motor inhibition and psychomotor dysfunction, and can be widely used in research related to depression and other relevant fields[1][2][3].
Molecular Weight:
433.93
CAS Number:
[2257428-48-9]
Formula:
C21H28ClN5O3
Target:
Adenosine Receptor
Application Notes:
MCE Product type: Reference compound1
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