AZD0011, a prodrug of AZD0011-PL (HY-182718), is an orally active arginase 1 inhibitor with an IC50 of 328 nM. AZD0011 undergoes in vivo hydrolysis to release an arginase inhibitor payload, inhibiting arginine hydrolysis, increases arginine levels in plasma and the tumor microenvironment. AZD0011 restores innate immune function and inhibits tumor growth. AZD0011 can be used for the research of cancer, such as fibrosarcoma[1].
Molecular Weight:
329.20
CAS Number:
[2374807-41-5]
Formula:
C14H28BN3O5
Target:
Arginase
Application Notes:
MCE Product type: Reference compound1
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