FT108 is a selective HDAC6 inhibitor with an IC50 of 0.026 µM. FT108 exhibits only modest in vitro activity against HDAC3 and HDAC8 with IC50 values of 6.68 and 4.07 µM. FT108 increases acetylation of tubulin and has little to no effect on acetylated histone H3 levels. FT108 lacks activity against myeloproliferative neoplasm cell lines, and does not suppress JAK2 phosphorylation or its downstream targets pSTAT3 and pSTAT5[1].
Molecular Weight:
320.34
CAS Number:
[2379645-28-8]
Formula:
C16H20N2O5
Target:
HDAC,Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound1
* VAT and and shipping costs not included. Errors and price changes excepted
