Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC50 of 2.2 µM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma[1].
Molecular Weight:
342.42
CAS Number:
[2380013-55-6]
Formula:
C17H18N4O2S
Target:
Hedgehog,PI4K
Application Notes:
MCE Product type: Reference compound1
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