RET-IN-32 is an orally active RET inhibitor with IC50 values of 0.285, 4.602 and 103.5 nM against wild-type, V804M and G810S mutant forms, respectively. RET-IN-32 inhibits the autophosphorylation of Tyr1062. RET-IN-32 completely suppresses tumor growth induced by BAF3-KIF3B-RET-WT xenografts. RET-IN-32 can be used in the research of thyroid cancer and lung cancer[1].
Molecular Weight:
593.68
CAS Number:
[2620629-32-3]
Formula:
C33H35N7O4
Target:
RET
Application Notes:
MCE Product type: Reference compound1
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