LLQ-45 is a covalent p53Y220C mutant protein agonist with an EC50 of 24.97 µM. LLQ-45 activates the anti-tumor function of p53Y220C through covalent modification, restores its DNA-binding ability and enhances its thermal stability. LLQ-45 selectively inhibits the proliferation of p53Y220C mutant tumor cells, suppresses cell growth and upregulates the expression of CDKN1A. LLQ-45 can be used in studies related to p53Y220C mutant cancers[1].
Molecular Weight:
307.35
Formula:
C17H17N5O
Target:
MDM-2/p53
Application Notes:
MCE Product type: Reference compound1
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