Tubulin-IN-66, CAS [[3110538-32-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-182753
Supplier Catalog Number:
HY-182753
Alternative Catalog Number:
MCE-HY-182753-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Tubulin-IN-66 is a tubulin (tubulin) and P-gp inhibitor with antiproliferative activity against cancer cells. Tubulin-IN-66 covalently binds to the Colchicine (HY-16569)-binding site at Cys239 of the beta-tubulin subunit, inhibits tubulin polymerization and disrupts the microtubule network. Tubulin-IN-66 inhibits P-gp function to overcome multidrug resistance. Tubulin-IN-66 arrests the cell cycle at the G2/M phase and induces apoptosis (apoptosis). Tubulin-IN-66 inhibits colony formation and migration of cancer cells. Tubulin-IN-66 can be used in the research of tumors such as breast cancer[1].
