Topoisomerase I-IN-21 is a promising topoisomerase I inhibitor with an IC50 of 18.79 µM. Topoisomerase I-IN-21 shows higher selectivity toward cancer cells over normal CD8+ cells. Topoisomerase I-IN-21 induces G0/G1 cell cycle arrest and apoptosis. Topoisomerase I-IN-21 activates the cGAS-STING pathway, leading to enhanced immune gene expression. Topoisomerase I-IN-21 can be used for research on leukemia, non-small-cell lung, colon, central nervous system, melanoma, ovarian, renal, prostate, and breast cancers[1].
Molecular Weight:
531.02
Formula:
C29H23ClN2O4S
Target:
Apoptosis,Topoisomerase
Application Notes:
MCE Product type: Reference compound
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