EGFR/BRAFV600E-IN-7, CAS [[3120155-78-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-182763
Supplier Catalog Number:
HY-182763
Alternative Catalog Number:
MCE-HY-182763-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
EGFR/BRAFV600E-IN-7 is a dual EGFR and BRAFV600E kinase inhibitor with human IC50 values of 0.12 µM, 0.80 µM, 1.20 µM for EGFR and 0.05 µM, 0.22 µM, 0.78 µM for BRAFV600E.EGFR/BRAFV600E-IN-7 interacts with key ATP-binding site residues of EGFR and BRAFV600E, including hydrogen bonding with EGFR Met769 and BRAFV600E Cys532.EGFR/BRAFV600E-IN-7 induces apoptosis via caspase-3/8/9 activation, modulates Bax and Bcl-2 expression, scavenges free radicals, and exhibits antiproliferative activity against human cancer cell lines.EGFR/BRAFV600E-IN-7 displays drug-likeness with no PAINS/Brenk structural alerts per in silico predictions.EGFR/BRAFV600E-IN-7 can be used for the research of colon cancer, pancreatic cancer, lung cancer, breast cancer[1].
Molecular Weight:
507.56
CAS Number:
[3120155-78-1]
Formula:
C28H21N5O3S
Target:
Apoptosis,Bcl-2 Family,Caspase,EGFR,Raf
Application Notes:
MCE Product type: Reference compound
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