MC4455 is a LSD1/PRMT5 dual inhibitor. MC4455 inhibits the LSD1/CoREST and PRMT5/MEP50 complex with IC50 values of 0.104 µM and 0.014 µM. MC4455 covalently binds to LSD1s FAD cofactor, stabilizes the LSD1/CoREST complex. MC4455 induces myeloid differentiation, alters transcriptomic profiles, drives alternative splicing changes, and impairs leukemic cell viability in AML cells. MC4455 can be used for the research of acute myeloid leukemia[1].
Molecular Weight:
457.57
Formula:
C27H31N5O2
Target:
Histone Demethylase
Application Notes:
MCE Product type: Reference compound
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