XL495 is an potent, selective and orally active PKMYT1 inhibitor. XL495 inhibits CDK1 Thr14 phosphorylation and induces KAP1 Ser824 phosphorylation in xenograft tumors. XL495 reduces tumor growth in colorectal and breast cancer xenograft models, and achieves tumor regression with DNA-damaging agents in colorectal cancer xenograft models. XL495 can be used for the research of cancer, such as breast cancer and colorectal cancer[1][2].
Molecular Weight:
308.33
CAS Number:
[3040320-93-9]
Formula:
C17H16N4O2
Target:
CDK,Wee1
Application Notes:
MCE Product type: Reference compound
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