PLX-4104 is an orally active BRD4 molecular glue degrader with a DC50 of 2 nM. PLX-4104 selectively promotes BRD4 degradation via DCAF11 recruitment, triggering ubiquitination and proteasomal breakdown. PLX-4104 inhibits cancer cell proliferation. PLX-4104 induces complete regression of AML xenograft tumors. PLX-4104 can be used for the research of acute myeloid leukemia[1].
Molecular Weight:
619.67
CAS Number:
[2851986-77-9]
Formula:
C32H26FN9O2S
Target:
Epigenetic Reader Domain,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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