DNMT1 Degrader-1, CAS [[2962943-72-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-182956
Supplier Catalog Number:
HY-182956
Alternative Catalog Number:
MCE-HY-182956-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
DNMT1 Degrader-1 is a selective DNMT1 degrader with an IC50 of 202.87 nM and a Kd value of 122 nM. As a molecular glue, DNMT1 Degrader-1 forms a ternary complex with DNMT1 and UHRF1, thereby triggering UHRF1-mediated ubiquitination and degradation of DNMT1, and inhibiting the enzymatic activity of DNMT1. DNMT1 Degrader-1 inhibits the proliferation of primary acute myeloid leukemia cells and exerts anti-tumor activity. DNMT1 Degrader-1 can be used for the research of acute myeloid leukemia[1].
Molecular Weight:
408.54
CAS Number:
[2962943-72-0]
Formula:
C24H32N4O2
Target:
DNA Methyltransferase,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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