Hsp70TAC BRD4 Degrader-1 is a PROTAC degrader targeting BRD4, with a KD value of 0.22 µM. Hsp70TAC BRD4 Degrader-1 forms a ternary complex with Hsp70 (KD: 5.13 µM), and specifically and efficiently degrades intracellular BRD4 via the ubiquitin-proteasome pathway. Hsp70TAC BRD4 Degrader-1 exhibits potent anti-tumor proliferative activity. Hsp70TAC BRD4 Degrader-1 can be used in studies related to triple-negative breast cancer and glioblastoma multiforme. (Pink: BRD4 ligand (HY-78695), Blue: HSP70 ligand (HY-182979), Black: linker (HY-B0236))[1].
