Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum[1][1].
Molecular Weight:
432.90
Purity:
97
CAS Number:
[212844-54-7]
Formula:
C20H25ClN6O3
Target:
CDK,Parasite
Application Notes:
MCE Product type: Reference compound
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