Pf20S-IN-1 is a selective inhibitor of the 20S proteasome beta5 subunit of Plasmodium falciparum. Pf20S-IN-1 exhibits antiparasitic activity against Plasmodium falciparum, with an EC50 of 20.1 nM against the Plasmodium falciparum W2 strain. Pf20S-IN-1 shows weak inhibitory effect on human 20S proteasome, has no obvious toxicity to human foreskin fibroblasts (HFF), and has a selectivity index > 25000. Pf20S-IN-1 can be used in malaria research[1].
Molecular Weight:
623.71
Formula:
C33H42FN5O6
Target:
Parasite,Proteasome
Application Notes:
MCE Product type: Reference compound
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