BRD4 degrader-7 (Compound ZZ1) is a CTLH-dependent BRD4 degrader and c-Glue with a DC50 of 489 nM. BRD4 degrader-7 converts to a sulfinic acid derivative inside cells, interacts with the basic pocket of YPEL5, mediates the bridging of BRD4 BD1 to the YPEL5 subunit of the CTLH E3 ubiquitin ligase, and thereby promotes the formation of a ternary complex. BRD4 degrader-7 can be used in research on Ewings sarcoma and leukemia[1].
Molecular Weight:
658.16
Formula:
C30H29ClFN5O5S2
Target:
Epigenetic Reader Domain,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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