TLR8 antagonist-2 (Compound 35) is a selective TLR8 antagonist with an IC50 of 0.032 µM against hTLR8. TLR8 antagonist-2 potently inhibits TLR8-dependent NF-kappaB activity in cells stimulated with TL8-506 (HY-20457). TLR8 antagonist-2 can be used in research related to inflammatory and immune diseases[1].
Molecular Weight:
418.53
Formula:
C25H30N4O2
Target:
NF-kappaB,Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
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