17beta-HSD10/CDK5-IN-1 is a poent dual 17beta-HSD10 and CDK5 inhibitor with IC50s of 2.44 and 0.26 µM for 17beta-HSD10 and CDK5, respectively. 17beta-HSD10/CDK5-IN-1 reduces ROS accumulation, attenuates pathological Tau phosphorylation, reduces Abeta plaque deposition, and ameliorates cognitive deficits in Alzheimers mice. 17beta-HSD10/CDK5-IN-1 can be used for the research of Alzheimers disease[1].
Molecular Weight:
383.44
Formula:
C21H25N3O4
Target:
17beta-HSD,Amyloid-beta,CDK,Reactive Oxygen Species (ROS),Tau Protein
Application Notes:
MCE Product type: Reference compound
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