CAII-IN-15 is a potent carbonic anhydrase II (CA II) inhibitor with a hCA II IC50 of 10 nM. CAII-IN-15 elevates cGMP levels, releases nitric oxide, reduces oxidative stress, and exhibits neuroprotective activity in vitro. CAII-IN-15 inhibits NLRP3 inflammasome activation, reduces neuronal apoptosis. CAII-IN-15 reduces Intraocular pressure (IOP) in rabbits. CAII-IN-15 can be used for the research of glaucoma[1].
Molecular Weight:
351.33
Formula:
C14H13N3O6S
Target:
Apoptosis,Carbonic Anhydrase,Interleukin Related,NOD-like Receptor (NLR),Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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