DHFR-IN-27 (Compound LA4) is an orally active DHFR inhibitor and antimalarial agent, with a Ki value of 1.71 nM against TgDHFR. DHFR-IN-27 reduces the parasitic load of Toxoplasma gondii in infected mice and prolongs the survival time of infected mice. DHFR-IN-27 exerts Antiparasitic effects against Toxoplasma gondii. DHFR-IN-27 can be used in the research of toxoplasmosis[1].
Molecular Weight:
420.89
Formula:
C20H25ClN4O4
Target:
Dihydrofolate reductase (DHFR) ,Parasite
Application Notes:
MCE Product type: Reference compound
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