TDP-665759 is an inhibitor for HDm2:p53 complex, and thus activates p53, inhibits STAT3 signaling pathway (EC50 of 5.90 µM) and the cell viability of p53 expressing A549R (IC50 of 7.02 µM). TDP-665759 induces apoptosis in HepG2. TDP-665759 exhibits antitumor efficacy in mouse models[1].
Molecular Weight:
706.44
CAS Number:
[787632-66-0]
Formula:
C31H34Cl2IN5O2
Target:
Apoptosis,MDM-2/p53,STAT
Application Notes:
MCE Product type: Reference compound
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