Cbl-b-IN-32 is a Cbl-b inhibitor with an IC50 of 6.83 µM. Cbl-b-IN-32 binds to the TKB-LH interface, stabilizes the inactive conformation of Cbl-b, engages Tyr363 via hydrogen bonds and water bridges, and forms hydrogen bonds with Phe261 and Phe263[1].
Molecular Weight:
310.31
Formula:
C16H17F3N2O
Target:
E1/E2/E3 Enzyme
Application Notes:
MCE Product type: Reference compound
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