FTO-IN-17 is an orally active and brain-penetrant FTO (m6A RNA demethylase) inhibitor with an IC50 of 1.1 µM. FTO-IN-17 stably binds the FTO catalytic pocket. FTO-IN-17 protects against Abeta1-42-induced toxicity while increasing global m6A levels and dampening pro-inflammatory gene (CXCL10, TNF-alpha) expression. FTO-IN-17 ameliorates anxiety-like behavior and rescues hippocampal-dependent spatial, recognition memory and neuroinflammation in Alzheimers disease mice models[1].
Molecular Weight:
370.42
CAS Number:
[1434867-98-7]
Formula:
C20H23FN4O2
Target:
CXCR,Fat Mass and Obesity-associated Protein (FTO),TNF Receptor
Application Notes:
MCE Product type: Reference compound
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