PI3K/mTOR-IN-22 is an orally active PI3K/mTOR kinase dual inhibitor with IC50 values of 400.5 nM and 8.2 nM. PI3K/mTOR-IN-22 downregulates phosphorylation of the AKT and mTOR, upregulates pro-apoptotic proteins Bax and caspase-3 and downregulates anti-apoptotic protein Bcl-2. PI3K/mTOR-IN-22 exhibits antiproliferative activity against cancer cells, induces apoptosis and ROS production, and reduces mitochondrial membrane potential. PI3K/mTOR-IN-22 exhibits antitumor activity in breast cancer mice models[1].
Molecular Weight:
610.68
Formula:
C28H34N8O6S
Target:
Akt,Apoptosis,Bcl-2 Family,Caspase,Mitochondrial Metabolism,mTOR,PI3K,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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