Topo I/II-IN-3 is a dual inhibitor of topoisomerase I/II (topoisomerase I/II), with an IC50 of 8.99 µM against Topo I and an IC50 of 26.92 µM against Topo II. Topo I/II-IN-3 induces DNA damage, elevates intracellular ROS levels, activates the mitochondrial apoptosis pathway, and exerts cytotoxicity against cancer cells. Topo I/II-IN-3 upregulates the expression of gamma-H2AX, p53, activated caspase-9, Bax and activated caspase-3, while downregulating the expression of Bcl-2. Topo I/II-IN-3 can be used in research related to breast cancer, liver cancer and gastric cancer[1].
Molecular Weight:
414.56
Formula:
C23H35FN6
Target:
Apoptosis,Bcl-2 Family,Caspase,MDM-2/p53,Reactive Oxygen Species (ROS),Topoisomerase
Application Notes:
MCE Product type: Reference compound
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