TDP1-IN-5 is a tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 2.2 µM. By targeting TDP1 both intracellularly and extracellularly, TDP1-IN-5 inhibits the NHEJ repair pathway, arrests the cell cycle at the G2/M phase, upregulates PIG3 to enhance ROS, and ultimately significantly potentiates ionizing radiation (IR)-induced DNA damage and apoptosis. TDP1-IN-5 can be used in the research of colorectal cancer[1].
Molecular Weight:
603.75
CAS Number:
[3115524-78-9]
Formula:
C34H45N5O5
Target:
Apoptosis,DNA/RNA Synthesis,Phosphodiesterase (PDE),Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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