GN-604 is a targeted drug conjugate (Targeted Drug Conjugate, TDC) formed by conjugation of GNS561 (HY-137978) with DN604, a Pt (II) complex. GN-604 selectively inhibits PPT1, induces lysosomal dysfunction, suppresses autophagy and triggers apoptosis. GN-604 promotes the targeted sequestration of Pt (II) inside cells, induces DNA damage and inhibits the proliferation of malignant cells. GN-604 is applicable to research related to triple-negative breast cancer[1].
Molecular Weight:
848.21
Formula:
C31H37ClN8O6Pt
Target:
Apoptosis,Autophagy,Cathepsin,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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