HLC40 is a MLL1 histone methyltransferase inhibitor with an IC50 of 0.82 µM by binding to WDR5. HLC40 inhibits proliferation of cancer cells, induces apoptosis and upregulates cleaved caspase-3 levels. HLC40 exhibits antitumor efficacy in a murine AML xenograft model[1].
Molecular Weight:
773.74
Formula:
C38H33F6N3O6S
Target:
Apoptosis,Caspase,Histone Methyltransferase,WDR5
Application Notes:
MCE Product type: Reference compound
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