MTHFD2-IN-8 is a selective MTHFD2 inhibitor with an IC50 of 0.066 µM. MTHFD2-IN-8 directly binds to intracellular mitochondrially localized protein MTHFD2 and accumulates selectively in tumor mitochondria. MTHFD2-IN-8 increases intracellular ROS levels, induces mitochondrial membrane potential depolarization, arrests cell cycle at G0/G1 phase, promotes apoptosis in cancer cells. MTHFD2-IN-8 inhibits tumor growth in a mouse colon cancer graft model[1].
Molecular Weight:
723.63
Formula:
C41H40BrO5P
Target:
Apoptosis,Methylenetetrahydrofolate Dehydrogenase (MTHFD),Mitochondrial Metabolism,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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