SL43 is an orally active and potent SOS1 inhibitor with a Kd of 0.16 µM. SL43 disrupts SOS1-KRAS interaction, inhibits SOS1-mediated nucleotide exchange on KRAS mutants, and suppresses RAS-MAPK signaling. SL43 exerts antiproliferative activity against KRAS-mutant cancer cells, induces early apoptosis and G1 phase cell cycle arrest, and reduces phosphorylated MEK and ERK levels. SL43 suppresses tumor growth in a colorectal cancer xenograft model[1].
Molecular Weight:
449.03
Formula:
C27H33ClN4
Target:
Apoptosis,ERK,MEK,p38 MAPK,Ras,SOS1
Application Notes:
MCE Product type: Reference compound
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