Necroptosis inducer 2 is a necroptosis inducer and copper chelator. Necroptosis inducer 2 chelates intracellular free copper ions, disrupts redox homeostasis, elevates ROS levels, disrupts mitochondrial membrane potential, and induces cancer cell necroptosis. Necroptosis inducer 2 upregulates the necroptosis markers p-MLKL and p-RIP3 expression. Necroptosis inducer 2 exhibits anti-tumor activity in mice. Necroptosis inducer 2 can be used for the research of cancer, such as triple-negative breast cancer[1].
Molecular Weight:
1114.08
Formula:
C72H56Cl2N2O2P2
Target:
Mitochondrial Metabolism,Mixed Lineage Kinase,Necroptosis,Reactive Oxygen Species (ROS),RIP kinase
Application Notes:
MCE Product type: Reference compound
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