TDP1-IN-6 (Compound 16b) is a TDP1 inhibitor with an IC50 of 1.52 µM. Combination of TDP1-IN-6 with Topotecan (HY-13768) enhances DNA damage, induces Apoptosis, triggers S-phase cell cycle arrest, and promotes Ferroptosis. TDP1-IN-6 can be used for the research of cervical cancer[1].