Fa-Au is a TrxR inhibitor. Fa-Au downregulates GPX4, induces oxidative stress, mitochondria-associated ferroptosis (ferroptosis) and immunogenic cell death. Fa-Au induces ROS production in hepatoma cells. Fa-Au remodels the tumor immune microenvironment via M1 macrophage polarization, dendritic cell maturation, CD8+ T cell activation and reduction of regulatory T cells. Fa-Au induces an anti-tumor immune feedback loop through the IFNgamma/STAT1/SLC7A11 axis. Fa-Au inhibits tumor growth. Fa-Au is applicable to hepatocellular carcinoma-related research[1].
Molecular Weight:
1429.19
Formula:
C64H70AuF6N4O12P
Target:
Ferroptosis,Glutathione Peroxidase,IFNAR,Reactive Oxygen Species (ROS),STAT,TrxR
Application Notes:
MCE Product type: Reference compound
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