MK-5661 is an orally active NaV1.8 voltage-gated sodium channel inhibitor with an EC50 of 4.3 nM. MK-5661 selectively inhibits peripheral nociceptive signaling mediators. MK-5661 reduces capsaicin-induced spontaneous nociceptive behaviors in humanized rats and attenuates capsaicin-induced skin flushing responses in rhesus monkeys. MK-5661 is applicable for pain-related research[1].
Molecular Weight:
479.42
CAS Number:
[2417328-24-4]
Formula:
C18H18F5N5O3S
Target:
Sodium Channel
Application Notes:
MCE Product type: Reference compound
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