HIF-2alpha-IN-18, CAS [[2709068-47-1]] Preis auf Anfrage

Product Overview

• Article Name: HIF-2alpha-IN-18, CAS [[2709068-47-1]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-183583
• Supplier Catalog Number: HY-183583
• Alternative Catalog Number: MCE-HY-183583-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

HIF-2alpha-IN-18 is a selective HIF-2alpha inhibitor with a human IC50 of 8.1 nM. HIF-2alpha-IN-18 binds to the HIF-2alpha PAS-B domain, induces conformational perturbations at the HIF-2alpha/ARNT dimerization interface, destabilizes the HIF-2alpha/ARNT heterodimer, and blocks HIF-2alpha-mediated transcriptional activity. HIF-2alpha-IN-18 inhibits hypoxia-induced expression of HIF-2alpha target genes EPO and SERPINE1, without inhibiting HIF-1alpha target genes PGK1 and PDK1. HIF-2alpha-IN-18 can be used for the research of clear cell renal cell carcinoma, hepatocellular carcinoma[1].

Product Properties

• Molecular Weight: 399.27
• CAS Number: [2709068-47-1]
• Formula: C18H8F7N3
• Target: HIF/HIF Prolyl-Hydroxylase

Application Notes

• Application Notes: MCE Product type: Reference compound