MK-1088 is an orally active A2A/A2B adenosine receptor antagonist with human A2A Ki of 0.31 nM, human A2B Ki 5.3 nM. MK-1088 blocks receptor downstream signaling, inhibits CREB phosphorylation and reverses adenosine-mediated immunosuppression. MK-1088 restores TNF-alpha release and enhances tumor immune surveillance. MK-1088 can be used for the research of cancer[1].
Molecular Weight:
468.53
CAS Number:
[2433765-51-4]
Formula:
C23H29FN8O2
Target:
Adenosine Receptor
Application Notes:
MCE Product type: Reference compound
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