WRN-IN-26 is an orally active Werner syndrome helicase (WRN) inhibitor with a human Ki value of 58.7 µM and an IC50 value of 0.026 µM. WRN-IN-26 selectively targets the cysteine residues of WRN. WRN-IN-26 induces the expression of p21 protein in MSI-H tumor cells. WRN-IN-26 inhibits the growth of MSI-H tumor cells and exhibits potent in vivo efficacy in MSI-H xenograft tumor models. WRN-IN-26 can be used for the research of microsatellite instability-high (MSI-H) cancers[1].
Molecular Weight:
560.58
CAS Number:
[3059172-54-9]
Formula:
C28H27F3N2O5S
Target:
DNA/RNA Synthesis,PAK
Application Notes:
MCE Product type: Reference compound
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