LPZ-51 is a Vibrio beta-lactam resistance sensor kinase (VbrK) inhibitor with a Ki value of 1.09 µM. LPZ-51 inhibits blaA gene expression at the transcriptional level by blocking the kinase activity of VbrK, reduces beta-lactamase synthesis, and does not affect bacterial growth. LPZ-51 acts synergistically with beta-lactam antibiotics. LPZ-51 decreases bacterial load, alleviates intestinal inflammation, and improves survival rate in zebrafish infection models. LPZ-51 can be used in studies related to Vibrio parahaemolyticus infection[1].
Molecular Weight:
486.54
Formula:
C27H27FN6O2
Target:
Bacterial,Interleukin Related,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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