DW-229 is a PROTAC degrader derived from Deferiprone (HY-B0568), targeting Fe(II)/alpha-ketoglutarate-dependent histone lysine demethylases (KDMs). DW-229 degrades KDM2A, KDM3A, KDM5B, KDM4A-C, KDM5C, KDM6B in breast cancer cells. DW-229 shows IC50 IC50 of 8.87 µM against MDA-MB-231 cells, with high cancer cell selectivity. DW-229 can be used for the research of breast cancer, liver cancer, prostate cancer, lung cancer[1].
Molecular Weight:
679.76
Formula:
C38H41N5O7
Target:
Histone Demethylase,PROTACs
Application Notes:
MCE Product type: Reference compound
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