Antileishmanial agent-43 is a 3,4,5-trisubstituted isoxazole with selective antileishmanial activity. Antileishmanial agent-43 shows IC50 values of 12.7 µM against Leishmania amazonensis promastigotes and 0.96 µM against intracellular amastigotes. Antileishmanial agent-43 induces ROS elevation, oxidative stress and mitochondrial dysfunction, resulting in lipid peroxidation, mitochondrial depolarization and ATP imbalance. Antileishmanial agent-43 causes cell shrinkage, phosphatidylserine externalization, plasma membrane permeabilization, and promotes autophagy. Antileishmanial agent-43 can be used for the research of leishmaniasis[1].
Molecular Weight:
460.42
Formula:
C23H17FN6O4
Target:
Autophagy,Parasite,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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