RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity[1].
Molecular Weight:
423.01
Purity:
98.81
CAS Number:
[1782573-67-4]
Formula:
C22H31ClN2O2S
Target:
Hedgehog
Application Notes:
MCE Product type: Reference compound
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