DQ-9 is a selective immunoproteasome beta5i inhibitor (IC50=0.0019 µM). DQ-9 generates additional inhibitory substances via iron-mediated intracellular activation, and induces oxidative stress, carbon-centered free radicals and macromolecular damage through its artemisinin domain. DQ-9 induces apoptosis in leukemia and multiple myeloma cells. DQ-9 exhibits selective cytotoxicity against leukemia and multiple myeloma cells by elevating the labile iron pool. DQ-9 can be used in the research of hematological malignancies (leukemia, multiple myeloma, mantle cell lymphoma, acute myeloid leukemia)[1].
Molecular Weight:
595.53
CAS Number:
[2803611-81-4]
Formula:
C33H46BNO8
Target:
Apoptosis,Proteasome
Application Notes:
MCE Product type: Reference compound
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