Antibacterial agent 344 is an antibacterial agent with potent biofilm inhibition (IC50 = 0.27 µM). Antibacterial agent 344 inhibits heme oxygenase (HemO), impairs iron homeostasis, virulence factor production, and motility. Antibacterial agent 344 synergizes with Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441), enhancing their efficacy and delaying the development of resistance. Antibacterial agent 344 improves bacterial-infected Galleria mellonella survival, and reduces bacterial load in mice wounds. Antibacterial agent 344 can be used for the research of Pseudomonas aeruginosa infections[1].
Molecular Weight:
398.46
Formula:
C18H14N4O3S2
Target:
Bacterial,Heme Oxygenase (HO)
Application Notes:
MCE Product type: Reference compound
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